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EXAMINE THE EFFECTIVENESS OF DROTAVERINE WITH PARACETAMOL IN PATIENTS PRESENTED WITH MODERATE OR SEVERE ABDOMINAL PAIN ASSOCIATED WITH ACUTE INFECTIOUS GASTROENTERITIS

Hakim Ali Abro, Imdad Ali Ansari, Tanveer Ahmed Ansari, Abrar Shaikh, Aftab Hussain Shah, Mumtaz Ali Chhutto

Objective: To examine the effectiveness and safety of drotaverine 80mg with paracetamol 500mg in patients presented with acute infectious gastroenteritis. Study Design: Randomized controlled trial. Place & Duration of Study: Department of Medicine, Chandka Medical College Hospital Larkana from 1st May 2019 to 31st October 2019. Materials and Methods: Two hundred patients of both genders with ages 18 to 55 years presented with moderate to severe abdominal pain due to acute infectious diarrhea were included in this study. Patients were divided into two groups Group A consist of 100 patients and received drotaverine HCL 80mg and paracetamol 500mg thrice a day for three days, Group B contains 100 patients and received paracetamol 500mg alone with same compliance. VAS was used to examine the intensity of pain. Relief in pain, global assessment of pain relief, decrease of stool frequency and complications were examined and compare the findings between both groups. Results: There were 58% males and 42% females in Group A with mean age of 29.55+10.45 years. In Group B 55% were males and 45% were females with mean age of 31.50+11.25 years. Pain frequency was significantly decreased in 30%, 65% and 90% at 1st, 2nd and 3rd days in Group A than 18%, 45% and 68% in Group B (p=<0.05). Pain severity significantly improved in Group A as compared to Group B (p=<0.05). Stool frequency improvement at2nd and 3rd day in Group A was 65% and 82% and in Group B it was 40% and 64%. Global improvement in abdominal pain by patients in Group A was 96% and in Group B it was 89% and by clinician it was 99% in Group A and 95% in Group B. Conclusion: The use of fixed-dose combination of drotaverine HCL 80mg and paracetamol 500mg is safe and effective oral therapy in patients with moderate or severe abdominal pain due to acute infectious gastroenteritis. Keywords: Abdominal pain, Infectious gastroenteritis, Drotaverine , Paracetamol.