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TITLE:

ANALYSIS OF CHEMOKINES AND OTHER NOVEL INFLAMMATORY MARKERS IN HYPERTENSION

AUTHORS:

Dr Abberah Ibrahim, Dr Aiman Khalid, Dr Sana Shakir

ABSTRACT:

Introduction: Hypertension is a major public health problem due to its high prevalence all around the globe. Objectives of the study: The main objective of the study is to analyse the chemokines and other novel inflammatory markers in hypertension. Material and methods: This cross sectional study was conducted in medicine department of DHQ Teaching Hospital, Sahiwal, during October 2019 to January 2020. All the data was collected according to the rules and regulations of authority. The data was collected from both genders of age between 30 to 50years. The demographic data of patients was collected through a systematically designed questionnaire. This questionnaire include all the information related to history, social and demographic values. Results: Our results shows significant differences among hypertensive and non-hypertensive patients in glycaemia, triglycerides, waist circumference, body mass index and hs-CRP. Our results showed that the level of antioxidants increases in hypertension patients due to increase in blood flow. The level of MDA, SOD, GSH and CAT vary in a different manner. The level of SOD become decreases due to hypertension. Conclusion: It is concluded that the link between hypertension and inflammation represents a new, stimulating field of research. Data now available from basic science studies show a complex mosaic of interplay between systemic inflammation, vascular cells activation, and structural changes in the arteries.

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