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THE CONTENT OF DNA IN CELLS OF ENDOMETRY WHEN USING SILVER-CONTAINING INTRAUTERINE DEVICES.

Petrov Yu.A., Kupina A.D.

Aim. The purpose of this study was to identify the proliferative properties of the endometrium, and therefore, to assess the risk of possible malignancy when using silver-containing IUDs by research of the DNA content in the epithelial cells of the glands of the uterine mucosa in women using this method of contraception. Materials and methods. The DNA content in the epithelial cells of the uterine mucosa glands was studied in 86 women of childbearing age with a normal menstrual cycle, having a history of one or more pregnancies and using silver-containing IUDs from 6 months to 7 years. Endometrial biopsy with the microcurette or obtaining endometrial scrapings were performed on the 8-10th or 19-23rd day of the menstrual cycle using silver-containing IUDs or immediately after their removal. Results. During the study it was revealed that the index of DNA accumulation in the glandular epithelium of the endometrium changed slightly. Only in the group of women who used IUDs for up to 1 year was the decrease in DNA content observed. In groups of women using silver-containing IUDs for a long time (more than 5–7 years), there is the tendency toward the decrease in the number of cells with intermediate DNA content and the increase with the tetraploid DNA set in the proliferative stage of the cycle (P> 0.05). Therefore, when using silver-containing IUDs in the glandular epithelium of the uterine mucosa, pathological proliferation of the endometrium is not observed, as well as when using indifferent plastic contraceptives. Keywords: silver-containing intrauterine contraceptive devices, DNA, oncological risk, menstrual cycle.