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STUDY TO KNOW THE EFFECT OF URINARY STONES ON PRETERM LABOUR: A RETROSPECTIVE ANALYSIS

Dr Rukhsana Perveen, Dr Bashir Ahmad, Dr Sadia Aslam

Antepartum nephrolithiasis is a multifaceted clinical situation that necessitates frequent intervention, such as placement of percutaneous nephrostomy tube (PCNT) placement and ureteral stent, particularly in the context of infection of the urinary tract. Aim: This study aim is to examine obstetric problems related with admittance for nephrolithiasis and to additional assess the present outcomes and practices for patients who need surgical interference Study Design: A Retrospective analysis. Place and Duration: In the Obstetrics and Gynecology Department Unit II of Nishtar Hospital Multan for two year duration from January 2018 to January 2020. Methods: This study comprised gravid females who were admitted for delivery. Antepartum nephrolithiasis admissions were recognized, as were PCNT placement or urological interference (ureteroscopy/ ureteral stent). Descriptive statistics were done, as was multivariable logistic regression to recognize prognosticators of preterm delivery and UTI. 405 cases of complex antepartum nephrolithiasis (0.14%) of 4080 births in this setting were identified. Results: 65% of these patients were conservatively treated, urological interventions were done in 20% (n = 81) and in 8.15% (n = 33); PCNT placement was done. Preterm delivery proportions augmented from a baseline of 6.50% for subjects without a stone to 10%% for cases with stones who were conservatively managed, who were done with urologic intervention have 12.01% risk of preterm delivery, and who had PCNT placement have 21% risk. In multivariate analysis; PCNT placement and urological intervention, conservative treatment individually amplified the preterm labor risk (all p <0.001). Conclusion: Antepartum nephrolithiasis is a correlated condition affecting one in 350 females, preterm labor and urinary tract infection rate are higher. Urethral stent intervention or PCNT placement increases independently the risk. However, the nephrostomy tube has increased risk of preterm labor in patients with antepartum nephrolithiasis and urinary tract infections. Key Words: Pregnancy, Nephrolithiasis, Premature, Urinary tract infection, Obstetric labor.