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TITLE:

RISK OF COMPLICATIONS OF PREGNANCY IN WOMEN WITH TYPE 1 DIABETES: A NATIONWIDE PROSPECTIVE STUDY

AUTHORS:

Dr. Asma Mushtaq, Dr. Muhammad Tanveer Ashraf, Dr. iqra Shah Jahan

ABSTRACT:

This study is based on nationwide cohort prospective for the investigation of neonatal, maternal and perinatal results of pregnancies in female patients specifically with “type 1 diabetes” according to data taken by PubMed Database for the 118 hospitals in the Netherlands. There were 323 women who become pregnant with type 1 diabetes between (as per data record of PubMed Database) 1st April 1999 and 1st April 2000. There were perinatal, neonatal and maternal outcomes of pregnancy. Pregnancies were planned (n=271) 84% and in pregnancy, the glycaemic control at initial was better with many women “HbA1c 7.0% (n=212) in 75% of the population as prescribed in PubMed Database), accordingly there were also reports for folic acid supplements that it was adequate (n=226) in 70%. Pre-eclampsia rates (40;12.7%) caesarean section (139; 44.3%), delivery of preterm (101;32.2%), maternal mortality (2;0.6%), perinatal mortality (9;2.8%), congenital malformations (29; 8.8%) and there was macrosomia (146; 45.1%) which is significantly greater as compared with general population. With one or more than one complication “neonatal morbidity” was very high (with the ratio of 260; 80.2%). The main congenital malformation incidence was importantly lower in these deliberated pregnancies than in unintended pregnancies as (4.2% (n=11) v 12.2 (n=6) with 95% confidence interval 0.13 to 0.88 and with relative risk 0.34. Besides high frequencies of intended pregnancies, in diabetes type 1 woman; there are results which showed good glycaemic initially control, folic acid high adequate rate and increased perinatal and maternal complications.

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