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ANALYSIS OF EFFECT OF INDOMETHACIN IN PREVENTION OF POST-ERCP PANCREATITIS PATIENTS

Dr. Noreena Saba, Dr. Muhammad Usman Mazhar, Dr. Quratul Ain Akber

Introduction: Among the gastrointestinal endoscopic procedures, endoscopic retrograde cholangiopancreatography (ERCP) has the greatest potential for complications. The most common complication is acute pancreatitis, with a reported overall incidence of 2%-10%; however, this can rise to 30% in the presence of certain risk factors. Aims and objectives: The basic aim of the study is to analyze the effect of Indomethacin in Prevention of Post-ERCP Pancreatitis patients. Material and methods: This randomized control study was conducted at THQ hospital, Yazman during 2018. There were total 200 patients who was selected for this study. Patients divided into two groups. One group was given per rectal indomethacin (2 suppositories 50 mg each) while other group given no suppositories. Results: A total of 200 cases fulfilling the inclusion/exclusion criteria were enrolled to compare the frequency of Post ERCP Pancreatitis in patients treated with or without rectal indomethacin. Age distribution of the patients was done, it shows that 30%(n=45) in Indomethacin and 29.33%(n=44) without Indomethacin group were between 15-50 years of age while 70%(n=105) in Indomethacin and 70.67%(n=106) without Indomethacin group were between 51-85 years of age, mean+SD was calculated as 56.28+8.39 and 55.72+7.84 years in both groups respectively. Conclusion: It is concluded that the frequency of Post ERCP Pancreatitis is significantly lower in patients treated with rectal indomethacin when compared to those without it

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