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EFFECT OF LIFESTYLE MODIFICATIONS ON PATIENTS QUALITY OF LIFE WITH GASTROESOPHAGEAL REFLUX DISEASE TAKING TREATMENT WITH PROTON PUMP INHIBITORS AND A PROKINETIC AGENT

Dr. Muhammad Mohsan Ali, Dr. Fasiha Mushtaq, Dr. Unaiza Anwar

Objective: The study to know whether Life style modifications has an beneficial impact on health and quality of life in patients of gastroesophageal reflux disease taking treatment with pantoprazole and itopride. Study Design: An open-label observational study. Place and Duration: In the Gastroenterology Department of Services Hospital, Lahore for one year duration from June 2017 to June 2018. Methods: Patients with GERD were given pantoprazole and for 8 weeks itopride. Health-related quality of life (HRQOL) was evaluated using a 8-item short form health questionnaire (SF-8) and GERD-specific quality-of-life questionnaires at the beginning of the study and one to two months after treatment. The scores of mental and physical components (MCS, PCS) and specific GERD scores were recorded. Results: Of the 187 patients checked, 41.08% were recommended for a modified lifestyle at the beginning of giving pantoprazole / itopride (Group A). In 33.3% suggesting that they should continue with lifestyle as recommended previously in Group B and in Group C 26.09% not recommended with any modification. For Group A, the PCS change at 8 weeks was 5.7 ± 8.1 and significantly higher than Group C (4.1 ± 7.5) and B (4.2 ± 7.6)(P <0.002). ). The MCS changes and GERDS were also significantly higher in Group A than in other groups. Changes in the current quality of life were higher significantly in A Group than in the other groups, regardless of the characteristics of the initial pt. Conclusion: Lifestyle change may be clinically useful in improving life quality in some of the patients with GERD treated with PPI. Key words: Quality of life, gastroesophageal reflux, proton pump inhibitor.

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