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TITLE:

A COMPREHENSIVE STUDY ON CORRELATION OF LEVEL OF OBESTATIN AND OBESITY

AUTHORS:

Dr. Umer Farooq, Dr. Khaliq ur Rehman, Dr. Asma Parveen

ABSTRACT:

Introduction: Obestatin was discovered by Zhang et al. in 2005, which is an anorectic peptide consisting of 23 amino acids and it is encoded by the same gene as ghrelin. The distribution of obestatin in human tissues is poorly understood. Aims of the study: The basic aim of the study is to find the correlation of level of obestatin and obesity. Methodology of the study: This study was conducted at Holly family hospital during 2018. The data was collected from 50 obese patients which was also suffering from heart and cholesterol diseases. Demographic factors were also asked to the student. Body mass index (BMI) and waist circumference (WC) were done for patients and controls as anthropometrical tests, while fasting serum glucose (FSG) measured using spectrophotometric technique. Results: Mean fasting obestatin levels was 0.450 ± 0.468 and 0.959 ± 0.889 respectively in hypertensive and normotensive obese and the difference of mean fasting obestatin levels between the both groups was statistically significant with p value 0.000. Conclusion: Obestatin plays very important role in obesity and it is directly correlated with blood glucose level. Furthermore, there was a clear relationship between obestatin and both BP and HOMA-IR, suggesting that obestatin might play a role in BP regulation.

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