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ANTIBIOTIC SUSCEPTIBILITY PATTERN OF ESCHERICHIA COLI ISOLATED FROM URINE SAMPLES OF URINARY TRACT INFECTION PATIENTS

Muhammad Owais, Aman Ullah, Muhammad Umar Nafees, Fazal Rahim, Muhammad Asif Zeb, Zubair Hussain, Abdul Malik, Shah Faisal Jamal

Background: Objective: To determine the antibiotic sensitivity pattern against Escherichia Coli in urine of urinary tract infection patients at Peshawar, Pakistan. Methodology: A descriptive cross-sectional study was conducted to determine the antibiotic susceptibility pattern against Escherichia coli at Peshawar. A total of 147 non-repetitive E. coli strains isolated from urine, were studied in this study. The antibiotic susceptibility pattern was determined by Kirby Bauer method, according to guidelines of Clinical Laboratory Standard Institute, USA. Sixteen different common antibiotics were tested against E. coli. Results: Out of total strains, 141 (95.91%) were sensitivity against Imipenem (10 μg) and 6 (4.45%) were sensitive against Nalidixic acid (30 μg). These are the highest and lowest sensitivity, recorded against E. coli. The sensitivity recorded against other antibiotics in percentage were 6.81% for Ampicillin (10 μg), 8.17% for TicarcillinClavulanic acid (75/10 μg), 9.53% for Amoxycillin-Clavulanic acid (20/10 μg), 15.64% for TrimethoprimSulfamethoxazole (1.24/23.75 μg), 15.64% for Cefotaxime (30 μg), 17.01% for Aztreonam (30 μg), 17.01% for Ciprofloxacin (5 μg), 17.01% for Trimethoprim (5 μg), 18.37% for Cefixime (5 μg), 19.05% for Ceftazidime (30 μg), 22.44% for Doxycycline (30 μg), 35.34% for Cefepime (30 μg), 59.18% for Nafcillin (1 μg) and 78.24% for Amikacin (30 μg). Conclusion: We concluded from this study that only Imipenem and Amikacin were the most sensitive anti-microbial agents. The sensitivity against Nafcillin and Amikacin was not significant, as compare to Imipenem. Key Words: Antibiotic sensitivity pattern. Escherichia coli. Urinary tract infection. Urine. Peshawar

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