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NEUROPROTECTIVE EFFECT OF SILIBININ AGAINST ISCHEMIA-REPERFUSION INDUCED CEREBRAL INFARCTION IN RATS

G. Devala Rao, S Praveen Begum*, Hanumanthu Penchalaiah

Present study was evaluated the neuroprotective effect of silibinin against against ischemia-reperfusion induced cerebral infarction in rats. Silibinin (10 and 20 mg/kg P.o.) was treated for 14 consecutive days followed performed carotid artery occlusion of 30 min then reperfusion period 24 hrs. After 24 hrs of reperfusion, the brains was isolated and subjected to measurement of percentage of cerebral infract volume and malondialdehyde, superoxide dismutase, catalase and inflammatory markers (MPO, TNF-α, IL-10) markers in the brain tissue. The results revealed that the silibinin (20 mg/kg B.Wt.) treated rats brain malondialdehyde levels were significantly decreased and increased superoxide dismutase, catalase and decreased inflammatory mediators like MPO, TNF-α, IL-10 brain tissue in intact group when compared with control group. Silibinin alleviated neurological protection in rats, and the mechanism may be related to augmentation in endogenous antioxidant defense and inhibition of oxidative stress in the rat brain. Keywords: Silibinin; Inflammatory mediators, Cerebral ischemic / reperfusion

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