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TITLE:

A REVIEW: TRADITIONAL ANTIULCER COMPOUNDS

AUTHORS:

Pattewar S.G., Sakhare R. S., Nagoba Shivappa N., Sugave B. K., Moholkar Aparark V

ABSTRACT:

Peptic ulcer is a break in the lining of the stomach, first part of the small intestine, or duodenum. The duodenumis the first part of the small intestine. Incompatible to popular belief, ulcers are not caused by spicy food or stress but other factors causes’ peptic ulcer main cause of peptic ulcer called H. pylori bacterial infection and long term use of NSAIDS medication. The main goals for treating a peptic ulcer include eliminating the underlying cause (particularly H. pylori infection or use of NSAIDs), NSAIDs inhibit the cyclooxygenase enzyme, Cyclooxygenase stop the secretion of prostaglandin. Prostaglandin responsible for the protection of gastric mucosa from H. pylori infection & other factor causing peptic ulcer. The most serious complications of peptic ulcer disease include hemorrhage, perforation, penetration, and gastric outlet obstruction. A number of drugs including proton pump inhibitors and H2 receptor antagonists are available for the treatment of peptic ulcer, but clinical evaluation of these drugs has shown incidence of relapses, side effects, and drug interactions. So an urgent need to evolve new herbal drug Bermuda grass for treating ulcer and easily available word wide,low cost,and effective with chronic condition.Botanical compounds with anti-ulcer activity include flavonoids(Apigenin, orientin, Luteoline & vitexine). Flavonoids responsible for the showing Anti-ulcer activity. Keywords: H.pylori infection, Bermuda herb, gastric mucosal erosion, peptic ulcer.

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