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REVIEW ON TRANSUNGUAL: A NOVEL DRUG DELIVERY SYSTEM

Gaddime Sonali B., Nagoba Shivappa N.*, Suryawanshi S. R., Vijayendra Swamy S. M

The nail disorders are mainly due to fungal infection. When the drug is given through oral or systemic route, the potency of drugs gets decreased at the site of action. To avoid this loss of drug potency topical route of administration is used. This review is mainly about transungual drug delivery which means transfer of drug across the keratinized nails to treat nail fungal diseases and increasing bioavailability of various drugs used for nail diseases. Nail diseases are mainly caused by fungal infections; fungi are most responsible for nail diseases. So treatment of such infections is not possible by oral administration of drugs, hence transungual drug delivery system has been introduced.The reason behind the limited therapeutic effectiveness of a current topical treatment is because they cannot sufficiently penetrate in the nail plate to transport a therapeutically sufficient quantity of antifungal drug to the target sites to eradicate the protection.The use of chemical permeation enhancer has been a common approach for enhancing trans-nail delivery of drugs. Physical permeation enhancement technique has not been explored for trans-nail drug delivery. This new therapy may reduce the need for hazardous systemic administration of oral anti-fungal drugs for nail infections. Also the analysis of the drugs penetration is a difficult task. Here in the present article a method to analyze the drugs permeated across nail barrier is suggested. Keywords: Naildisorder, antifungal drug, permeation enhancer, fungal infection, etc.

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