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A COMPREHENSIVE STUDY ON CORRELATION OF SMOKING AND SURVIVIN IN ORAL SUBMUCOUS CARCINOMA

1Dr. Tayyab Tufail, 1Dr. Mudasir Shah, 1Dr. Haseeb Uddin

Introduction: Oral sub mucous fibrosis (OSF) is a premalignant disorder associated with the chewing of areca nut. After transformation into squamous cell carcinoma (SCC), it is also responsible for mortality. The combination of areca nut and tobacco has led to a sharp increase in the frequency of OSF. Aims and objectives: The basic aim of the study is to find the correlation of smoking and survivin in oral sub mucous carcinoma in local population of Lahore. Material and methods: This study was conducted at Punjab dental hospital, Lahore during 2018. The data were collected from 100 patients of both genders. Tumors, OSF and healthy mucosa were taken at the time of surgical resection. Punch biopsy was performed under local anesthesia, and the sample size measuring 5mm was taken from the affected buccal mucosa. After 24 hours, specimens were fixed in 4% buffered formalin solution. Three sections each of 3 to 4 microns thickness were cut from each selected block using a rotary microtome. Two respective slides were made from one tissue specimen. Results: In a study to detect survivin levels in saliva in patients with OSCC by using a specific ELISA test it was found that the survivin levels in patients with OSCC are significantly higher than those of healthy subjects and the difference in survivin levels between early stages of OSCC and control subjects were found to be significant. Chi square test was applied to calculate level of significance with respect to duration of smoking and insignificant results were obtained. Conclusion: It is concluded that survivin in oral premalignant lesions can be a marker for progression to malignancy. Survivin in oral premalignant lesions can be a marker for progression to malignancy.

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