1Khawlah Alzaben, 2Saroona Haroon, 3Tarak Damak, 1 Ibtehaj Alharbi
Background Retroperitoneal Liposarcoma can mimic several masses; including benign tumors like lipoma, angiomyolipoma. Medical literature usually describes cases where an angiomyolipoma were masqueraded as Liposarcoma. To the best of our knowledge, this is the second case in medical literature were a Liposarcoma was mimicking an angiomyolipoma. Case report We report a rare case of a 55-year-old male presenting to the clinic complaining of abdominal enlargement and signs of renal failure. CT scan showed a huge heterogeneous mass arising from the lower pole of the right kidney. The mass was found to be a retroperitoneal liposarcoma mimicking an angiomyolipoma. Conclusion Distinguishing liposarcoma from angiomyolipoma is important as liposarcoma are usually associated with a high reoccurrence rate that needs frequent follow-up. One of the important markers is the MSA/ HMB45/ Melan stain, which, if positive, usually associated with angiomyolipoma. Keywords: liposarcoma; retroperitoneal liposarcoma; angiomyolipoma; giant; rare.