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TITLE:

IL1B GENE POLYMORPHISM IN CHILDREN WITH GINGIVAL RECESSION

AUTHORS:

Saleev R.A., Mamaeva E.V., Akisheva A.R., Valeeva I.Kh., Valeeva E.V., Akhtereeva A.R., Saleeva G.T., Imamieva R.D., Ahmetov I.I

ABSTRACT:

Gingival recession is a multifactorial disease. Various factors are involved in its development and progression. The main factor is currently believed to be genetic, as a result of a genetically incorporated wrong ratio of size, shape (signs of curvature) of the roots relative to the thickness of the alveolar bone of the jaw. The aim of the research was to study the association of the polymorphism -511 C / T, (rs16944) of the interleukin-1b gene (IL1B) with a predisposition to the development of gingival recession in children and conditionally healthy donors living in the territory of the city of Kazan in the Republic of Tatarstan. The study included 84 children (41 girls, 43 boys) with gum recession. The age of the examined children was from 6 to 12 years old (average age 8.12±1.06 years), and the control group consisted of 283 conditionally healthy donors not having a gum recession. DNA was isolated from buccal epithelial cells by the sorbent method, in accordance with the attached instructions for use of the «AmpliPrym DNA-Sorb-B» DNA Extraction Kit («NextBio», Russia). It was shown that in the group of children with gum recession, the SS genotype was predominantly determined (45.2%). The ST genotype in the comparison groups and with the gum recession were unequivocal (39.2% and 39.5%, respectively, of the cases). T-allele carriers were more common in the comparison group (healthy) (P = 0.089). Key words: gum recession, children, cytokine IL1B genes, association, genetic polymorphism.

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