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PREECLAMPSIA DISORDER, PATHOGENESIS, PRESENTATION, AND MANAGEMENT

Hanaa Hamed Mohammed Aljehany , Amani Salem Ahmed AlGhamdi , Zina Abdelkrim Zahidy , Johar Mohammed Aljohar , Shimaa Mohamed Sayed Abdelall , Alaa Adel Shabekni , Bayan Jamal Alibrahim , Abdulrahman Mashan Almutairi , Afnan Abdulaziz Alshaifani , Alaa Salem Eid Alharbi , Ameerh Saleh Aljbeery , Ziyad Abdullah Siraj Mandura , Afaf Ahmed Mohamed Bashal , Ruba Abdulrahman Saleh

Abstract :

Introduction: Preeclampsia is considered a disorder of pregnancy defined as hypertension and proteinuria of more than 300 mg/day. It is considered a highly serious disorder which could potentially lead to maternal and fetal morbidity and mortality. The aim of this review article is to summarize the pathogenesis of preeclampsia and potential management plans according to these pathophysiological changes. Preeclampsia remains to elude doctors and researchers as an enigma or a “disease of theories”. Recently, there has been advancement made in the last fifteen years that helped us understand the pathogenesis, which gives great hope to recognize and rational treatment. Though the pathogenesis of the disorder has not yet been fully understood, recent data suggest that there’s imbalance in angiogenic factors responsible for the clinical symptoms of the disorder and could possibly explain why specific populations are at higher risk than the others. Aim of work: In this review, we will discuss preeclampsia disorder, pathogenesis, presentation, and management. Methodology: We did a systematic search for preeclampsia disorder, pathogenesis, presentation, and management. using PubMed search engine (http://www.ncbi.nlm.nih.gov/) and Google Scholar search engine (https://scholar.google.com). All relevant studies were retrieved and discussed. We only included full articles. Conclusions: Recently, there has been great advancement in the management of preeclampsia, if not transformed, our understanding of pathogenesis of preeclampsia to the extent that new management and predictive markers are in sight. But, research studies must be translated to the clinical world, which should be prioritized, particularly in terms of funding. Concern for hypertension disorders of pregnancy are gaining more attention as potential mothers delay their childbearing years which elevate their risks for these disorders. Prevention and management measures continue to be very limited. With the more epidemiologic data of the persistent vascular effects of preeclampsia after delivery, both patients and doctors need to be aware so that proper surveillance and treatment can commence. Key words: preeclampsia disorder, pathogenesis, presentation, and management.

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