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A CROSS SECTIOANL STUDY ABOUT MEASURING CRP LEVEL BY VALUATION OF STRESS RESPONSE AFTER OPEN CHOLECYSTECTOMY AND LAPAROSCOPIC CHOLECYSTECTOMY

Dr. Kaynat Shafique, Dr. Angbeen Zafar, Dr. Hala Shafique

Abstract :

Objective and Design: We designed a cross-sectional and observational study to measure the CRP Level by evaluating operative stress response after Laparoscopic Cholecystectomy (LC) and Open Cholecystectomy (OC). Venue and Time-Period: This study was managed in the General and Vascular Surgery Department of Bahawal Victoria Hospital, Bahawalpur and the time period was of 11 months year (June, 2017 to April, 2018). Methods: We enrolled patients for the study, who were admitted in our hospital with symptomatic cholelithiasis disease. Patients admitted in our hospital on the bases of their demographic data and pathologic diagnosis for the diagnostic of cholelithiasis and then decided for cholecystectomy. The cases were randomly allocated to open cholecystectomy and laparoscopic cholecystectomy groups. CRP levels were measured preoperatively and postoperatively. Results: All patients (total=92, men=51, women=41) admitted for the Laparoscopic Cholecystectomy LC and Open Cholecystectomy OC have 38.19 ±9.263the mean age and the SD. The two randomized groups of LC and OC were undergoing for the comparison of CRP levels for the postoperative follow up of 4 hours,8 hours and 24 hours. Postoperative mean CRP readings in mg/dl for LC group were 8.12 ±2.89, 15.19 ±6.63 and 25.11 ±9.92 and for OC group were11.90± 1.52, 22.67 ±3.72 and 35.28 ±6.34 after 4, 8 and 24 hours respectively. Means of both groups were compared by T-Test and found no significant difference between two, i.e P-value is 0.000. Our study did not face any complication and mortality case. Conclusion: CRP level is a beneficial indicator tool to measure the postoperative stress response in patients after Laparoscopic Cholecystectomy (LC) and Open Cholecystectomy (OC). Keywords: Laparoscopic Cholecystectomy, Open Cholecystectomy, CRP level, Stress response, Cholelithiasis

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