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TITLE:

ROLE OF TRANS-FATTY ACID AS RISK FACTOR FOR INSULIN RESISTANCE AND TYPE-2 Diabetes IN ETHNIC GROUPS OF QUETTA CITY, BALOCHISTAN PAKISTAN

AUTHORS:

Fatima Yousaf Ali *, Asim Iqbal, Kashif Kamran

ABSTRACT:

Objectives: Type 2 diabetes; a growing global health problem, has a complex etiology involving many interactions between genetic and environmental factors. Therefore, we examined association between the consumption of trans-fatty acids (TFA diet) and fasting lipid profile in patients suffering with type-2 diabetes. Materials and Methods: This study was performed at Sahib-Az-Zaman medical hospital and Fayyaz diagnostic laboratory at Quetta city during August 2017 to November 2018.A total 400 participants given their written consent for this comparative clinical trial. A questionnaire was designed to record the detailed history about the consumption of TFA. The fasting glucose and lipid profile was performed by overnight fasting of 12 hours. The participants were divided into Group I (consuming trans- fat free lipid) and group II (consuming trans-fat lipid). The results of the two groups were compared in order to determine the correlation of different parameters. Results: Significant interaction was recorded among certain parameters of trans-fats consuming subjects like serum cholesterol shows a positive correlation with triglyceride, Glucose, total lipids, HDL and LDL. We have recorded high prevalence of type-2 diabetes in Pashtun ethnicity due to massive intake of fatty food. Conclusion: Our results suggest a direct significant association between consumption of TFAs with parameters of lipid profile. Our findings also highlighted the possible drastic effects due to excessive intake of TFAs. Key words: TFAs, Trans Fatty Acid, T2DM, type-2 diabetes, lipid profile.

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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.