ResearcherID - CLICK HERE Scientific Journal Impact Factor (SJIF-2020) - CLICK HERE

LOCATE THE OVERALL PREDOMINANCE OF LEPROSY RESPONSES IN DIFFERENT TYPES OF DISEASE AND THE HISTOPATHOLOGICAL HIGHLIGHTS OF THE RESPONSE

Muhammad Hussain Khan Sajawal, Muhammad Rizwan, Muhammad Asad Jamal

Objective To locate the overall predominance of leprosy responses in patients with uncleanliness going to dermatology to understand the office, the example of responses in different types of disease and the histopathological highlights of the response. Methods: Our current research was led at Mayo Hospital, Lahore from October 2018 to September 2019. The review was a longitudinal, institution-based survey. A total of 320 cases of disease went to the Dermatology Division Out-Tolerant Division (OPD) of a tertiary consideration’s clinic in Pakistan. Results: Out of 324 patients with the disease, 62 (19.5%) were analyzed for leprosy responses and the relative prevalence of Type 1 and Type 2 responses was 10.4% and 7.9%, individually. Out of 64 patients, 54 met the consideration criteria and were considered for final evaluation. Leprosy responses were baseline in patients over 34 years of age. Prevalence among men was high and the ratio of men to women was 4.6:1. More than 64% of patients had a place below the poverty line. Farmers and workers have been gradually influenced. Almost 63% of patients were literate, but most of them had some essential training. The type 1 response was progressively basic in patients with BT (53%), while the type 2 response was more often observed in LL patients (32%). Erythema and expansion of skin lesions, neuritis and swelling of the hands and feet were the main characteristics of the type 1 response. New harvests of delicate transient pimples, joint pain, neuritis and fever were the basis for the type 2 response. Traditional histopathological highlights were available in the 50 slides analyzed. In patients with a type 1 response, lymphocyte invasion (97%), cutaneous edema (94%), epithelioid cells (78%) and Langhian sorted goliath cells (17%) were the normal histological findings. Edema and foamy macrophages were detected in all cases of patients who responded to type 2 therapy. In any case, polymorphonuclear leukocytes and vasculitis were found in 22 (96%) and 17 (74%) patients, individually. Conclusion: Leprosy responses, type 1 and 2, occur in approximately 23% of patients with uncleanliness. Early recognition is justified to avoid difficulties. Keywords: Leprosy, lepra reaction.

FULL TEXT