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Kovuru.Saisankerthana, Dr. P. Polireddy, Dr.Vivek V. Byahatti


Epilepsy is one of the most common serious neurological conditions. In contemporary society, the frequency and importance of epilepsy can hardly be overstated from the epidemiologic studies. The plant Sebastiania chamaelea belonging to the family of Euphorbiaceae. Here Phyto chemical screenimg and anti convulsant activity of Sebastiania chamaelea evaluated. The phytochemical screening showed the presence of alkaloids, terpenoids, tannins, sterol’s,flavonoids and carbohydrates. Present study was under taken to screen anti convulsant activity of Sebestiana chamelea. The drug was administered in the form of hydro alcoholic extract orally and the effect was noted at two doses. The drug was found quite safe by oral route as animals tolerated drug up to the dose of 2.00 gm. Following interpretations are worth of note in the present study: The drug is quite safe by oral route as animals tolerated drug up to the dose of 2.00 gm/Kg b.w. in rats.The drug showed significant antiepileptic activity in both strychnine induced seizures. The anti epileptic effect was more pronounced at higher dose of the test drug than the lower dose. The drug at higher dose protected the entire animal from death and percent protection from death in lower dose was 33%. Present study indicated that Sebestiana chamelea has a potential for developing it as anti epileptic drug, however more refined studies are needed to evaluate it for exact mechanism of action and chemical constituent of Sebestiana chamalea responsible for the anti epileptic action. Keywords: Sebastiania Chamaelae, Phytochemical screening, anti convulsant activity.


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