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A STUDY ON THE F DIFFERENT BIOMARKERS FOR PROSTATE CANCER

Dr Mamoona, Dr Haaris Ali Arshad, Dr Abdullah

Objective: In this research study the use of prostate specific antigen (PSA) and it sub type (fPSA %) free fraction of total prostate specific antigen percent, (PSAD) prostate specific antigen density as a bio marker for prostate cancer (PCa) is discussed. This research study was conducted to find diagnostic tool in prostate cancer such that serum totals PSA, fPSA% and PSAD. In terms of their sensitivity, specificity and overall accuracy. Methodology: 48 patients of prostate cancer were admitted in Bahawal Victoria Hospital Bahawalpur from January 2015 to January 2017. To find out the ratio of PSA and fPSA% in serum we used ELISA (Enzyme linked immunosorbent assay) this kit is present anywhere in medical lab. Data related to volume of prostate which is determined by abdominal sonography were used to count prostate specific antigen density and histology of the surgically cut out prostatic organ was conducted for laboratory verification of PCa for a rest of patients. Diagnostic awareness, particularity and accuracy of serum total PSA, fPSA% and PSAD were counted by using basic formulae against microscopic examination of tissue. Results: Microscopic study of tissue showed that in 48 patients forty-one suffer from prostate cancer the mean age of patients were 69.2±8.1 years old. In these 39 patient 7 cases are those who suffer from Nodular Hyperplasia of Prostate (NHP) with prostate-specific tumor markers of these patients were commonly in the normal ranges. The awareness, particularity and overall diagnostic accuracy for PCa of serum total PSA (at cut off value of greater than ten ng/ml) were 88 (48%), 88 (90%) and 80% for serum free PSA (at cut off value of less than 23%), were 90. 68%, seventy-seven.80% and 90% and for PSA density (at a cut off value of greater than point 15 ng/ ml/cm3), were initiate to be 90% 88 and 90% individually. Microscopically, 27 (65.46%), 13 (31.7%) and 1 (2.44%) cases were divided as poorly separated, normally separated and strongly separated carcinoma individually and amazing superiority had very good interaction with all prostate-specific tumor markers. Conclusion: These outcomes stress that diverse prostate-specific tumor markers have great diagnostic prediction with fPSA% and PSA Density have normally best diagnostic accuracy as compare to serum tPSA for PCa. KEYWORDS: Microscopically, Prostate-Specific, Interaction, Carcinoma, Diagnostic, Antigen, Biomarker,

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