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CYTOMEGALOVIRUS INFECTION AND ITS ANTINUCLEAR ANTIBODY AMONG PATIENTS OF VITILIGO

Dr Sadaf Sultan, Dr Faiqa Ijaz, Dr Sohail Ahmad

Recently, using polymerase chain reaction (PCR) technique, cytomegalovirus DNA has been detected from discolored white spots in patients with vitiligo. Reactivation of infection and sporadic anti-CMV IgM circulating among patients infected with cytomegalovirus have been reported for years. Aim: The purpose of this study was to determine cytomegalovirus and antinuclear antibody infection in patients with vitiligo. Place and duration: From March 2019 to August 2019 for six months at the Medical and Dermatology Department of the Khyber Teaching Hospital Peshawar. Methods: We studied 26 patients with clinical manifestations of vitiligo and some with medical history for years. Seven of these patients (26.92%) were positive for anti-CMV IgM, which showed the presence of cytomegalovirus infection in patients with vitiligo which was significantly different from control (p <0.0001). Results: Of these 7 IgM positive CMV 6 patients (85.71%) were also positive for antinuclear antibodies (ANA). On the other hand, 7 cases (36.84%) of 19 negative cases for anti-CMV IgM were positive for antinuclear antibodies (ANA), so the difference was statistically significant (p <0.05). Conclusion: The incidence of anti-CMV IgM was higher in patients with active vitiligo than in patients with stable vitiligo (p <0.02). Key words: Antinuclear antibody (ANA), vitiligo, cytomegalovirus (CMV).

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