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FREQUENCY OF POST- PHOTOTHERAPY THROMBOCYTOPENIA IN HYPERBILIRUBINEMIC NEONATES

Dr. Asif Javeed, Dr. Muhammad Anwar, Dr. Sadaf Bashir

Objective: To determine the frequency of post- phototherapy thrombocytopenia in hyperbilirubinemic neonates. Material and methods: This cross sectional study was conducted at Department of Pediatric Medicine, Multan Medical and Dental College /Ibne Sina Hospital Multan from May 2018 to November 2108 over the period of 6 months. Total 103 neonates apparently healthy, who developed indirect hyperbilirubinaemia and required phototherapy irrespective of gestational age and birth weight. The indication of phototherapy was based on the guidelines of American Academy of Pediatrics 2004. Post- phototherapy thrombocytopenia was assessed. Results: In present study total 103 neonates were selected. Mean gestational age of neonates was 38.69 ±4.33 weeks and mean birth weight was 2.8 ± 0.6 kg. Out of 103 neonates, post- phototherapy thrombocytopenia was found in 47 (46%) neonates. Post- phototherapy thrombocytopenia was noted in 26 (46.4) male neonates and in 21 (44.7%) female neonates. Insignificant association of gender with post- phototherapy thrombocytopenia was noted with p value 0.8625. Post- phototherapy thrombocytopenia was found in 22 (36.7) neonates of ≥ 37 weeks groups and in 25 (58.1) neonates of < 37 weeks group. Statistically significant association between gestational age and post- phototherapy thrombocytopenia was observed with p value 0.0503. Conclusion: Results of this study showed a higher rate of post- phototherapy thrombocytopenia in hyperbilirubinemic neonates. Gender and birth weight of neonate had no effect on development of post- phototherapy thrombocytopenia. But gestational age, type of phototherapy and duration of phototherapy was significantly associated with development of post- phototherapy thrombocytopenia in hyperbilirubinemic neonates. Keywords: phototherapy, thrombocytopenia, hyperbilirubinemic, neonates

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