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DETERMINATION OF SERO-PREVALENCE OF DENGUE AND ITS ASSOCIATION WITH BIOCHEMICAL AND HEMATOLOGICAL PARAMETERS

Dr Sobia Khan, Dr Usman Tariq, Dr Azeem Sarwar Gill

Objectives: The purpose of this study is to find out the incidence of acute Dengue in Holy Family Hospital Rawalpindi and its association with the biochemical as well as haematological parameters. Methodology: The duration of this research work was from March 2016 to December 2019. We diagnosed the patients serologically suffering from acute Dengue if there was reactive dengue virus antigen of NS-1, IgG or IgM. Results: Out more than 2000 patients suspected to present with Dengue, we diagnosed 1153 patients serologically with acute Dengue, causing a Sero-prevalence of 64.9%. There was a lower average count of platelets 89 x 109/L in the patients who were Dengue positive in comparison with the patients who were dengue negative (171.0 x 109.0/L) (P < 0.00010). Average total count of white blood cells was also less in the patients who were Dengue positive (4.7 x 109/L vs 7.2 x 109/L; P < 0.00010). There was a high average hematocrit in the patients suffering from acute Dengue (42.5% vs 40%; P < 0.00010). Likewise, there was a higher level of serum alanine transaminase among patients suffering from acute Dengue (108 U/L vs 54 U/L; P < 0.00010). Conclusions: There was much high prevalence of acute Dengue in our institute in these three years of study duration. The most critical parameter which was strongly associated with the acute Dengue was count of platelets. Count of platelets was much low in the patients suffering from Dengue. KEYWORDS: Count, Platelets, White Blood Cells, Parameter, Serum, Prevalence, Acute, Dengue,

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