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CORRELATION BETWEEN MATERNAL PROLACTIN LEVEL AND CORD BLOOD PROLACTIN AND COMPARISON OF PROLACTIN LEVEL IN NEWBORNS DELIVERED FROM NORMAL PREGNANCY AND PREGNANCY WITH COMPLICATIONS

Dr Usman Tariq, Dr Azeem Sarwar Gill, Dr Sobia Khan

Objectives: This research work carried out to examine the association between maternal prolactin level and CBP (Cord Blood Prolactin), the association between Cord Blood Prolactin and weight at the time of birth and to provide the comparison of the Cord Blood Prolactin in newborns of females having normal pregnancy and the females present with complicated pregnancy as gestational Hypertension GDM (Gestational Diabetes Mellitus) and preterm labor. Methodology: The duration of this study was from August 2019 to November 2019. In this research work, we included 32 females who delivered at Children Hospital, Lahore and their thirty-two newborns. We collected 5 ml blood before labor and also took 5 ml cord blood after expulsion of placenta. The utilization of the fluorescence immunoassay was carried out for the analysis of the prolactin level of maternal and cord blood. Results: The level of cord blood prolactin was much high in the neonates born to females with hypertension (405.280 ±77.520 ng/ml) as compared to the females with normal pregnancy (244.8±60.8 ng/ml), P=0.00. The level of cord prolactin in the gestational hypertension group was much higher than the groups of Diabetes Mellitus (P=0.0060) &preterm labor (P=0.00). We found no significant difference in the level of Cord Blood Prolactin in neonates of diabetic females and females with normal pregnancy (299.280 ±37.010, 244.8±60.8 ng/ml respectively, P=0.0530). There was lower cord prolactin in the newborns of preterm labor (204.570 ±22.900 ng/ml) as compared to the newborns of normal pregnancy (244.8± 60.8 ng/ml), but this difference was not significant statistically, P=0.1180. We found a positive association between the cord &maternal prolactin level (P=0.00) and between birth weight &cord prolactin (P=0.0180). Conclusion: Cord Blood Prolactin level is high in the neonates of females with hypertension and low in the neonates of females having preterm delivery. There is no impact of Diabetes Mellitus on the level of Cord Blood Prolactin. KEYWORDS: Preterm, Pregnancy, Diabetes Mellitus, Hypertension, Neonates, Cord, Prolactin, Placenta.

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