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EVALUATION OF ANTI-DIABETIC ACTIVITY OF SAFOOF-E-ZIABETUS DULABI AGAINST METFORMIN IN STREPTOZOTOCIN INDUCED DIABETIC RATS.

*Sk.Syed Hussain,Amreen Qureshi, Dr. Anupama Koneru

In the present study, the anti-diabetic activity of a polyherbal unani formulation Safoof-e-ziabetusdulabi is evaluated in streptozotocin induced diabetic rats. Diabetes was induced using streptozotocin at a dose of 55mg/kg i.p. The study was carried out for 8 weeks and various biochemical parameters were evaluated. On treatment with SZD 200mg/kg and 400mg/kg effectively showed increased body weight of diabetic rats when compared with disease control group. It was also observed that the blood glucose levels and HbA1c levels were reduced in SZD 200mg/kg and 400mg/kg treated groups when compared with disease control.Liver function test was performed in the study to evaluate the safety profile of SZD. On treatment with SZD at 200mg/kg and 400mg/kg effectively decreased Alkaline phosphatise, SGPT, SGOT and total bilirubin when compared with disease control group. Thus the results suggests that SZD possess antidiabetic activity. Keywords: HbA1c, Streptozotocin, diabetes, Ficusracemosa, Punicagranatum, Mangiferaindica, Phyllanthus emblica, Coriandrum sativum.

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