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APPROACHES OF BUCCAL DRUG DELIVERY SYSTEM

K. Malleswari*, D. Rama Brahma Reddy, D. Anil Reddy

Buccal drug delivery leads direct access to the systemic circulation through the internal jugular vein by passes drugs from the hepatic first pass metabolism leading to high bioavailability. Buccal route is an attractive route of administration for systemic drug delivery. Buccal bio adhesive films, releasing topical drugs in the oral cavity at a slow and predetermined rate, provide distinct advantages over traditional dosage forms for treatment of many diseases. This article aims to review the recent developments in the buccal adhesive drug delivery systems to provide basic principles to the young scientists, which will be useful to circumvent the difficulties associated with the formulation design. Keywords: buccal drug delivery system, film, bioadhesive.

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