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THE EFFICACY OF INTRAVENOUS POLYMIXIN (COLISTIN) AGAINST MULTIDRUG RESISTANT ORGANISMS IN CHILDREN WITH SEPSIS

Hareesh, Mohammad Iqbal

Background: Over the past few decades, multi-drug resistant (MDR) recurrence of polymixin remission, particularly in serious patients, with gram negative infections, Polymixin was less toxic than before. Objective: To determine the efficacy of intravenous polymixin (Colistin) against multidrug resistant organisms in children with sepsis Material and Methods: This case series study was conducted at department of Pediatrics, Ziauddin University Hospital, Karachi from November 2017 To May 2018. Total 195 patients who were culture positive (urine, blood, tracheal aspirate, CSF fluid) for MDR organisms were included. Polymyxin at dose of 5 mg/kg/day, in 3 divided doses was started and continued for 21 days. Success of the medication was assessed according to microorganism growth in con¬trol cultures, together with clinical and radiographic improvements after 48 hrs of medication. Descriptive statistics were calculated. Stratification was done and post stratification chi-square test was applied. P-value ≤ 0.05 was taken as significant. Results: There were 78.5% male and 21.5% female patients. Mean age was 6.19±2.5 years. Mean weight after 48 hours of treatment was 2.36±0.68 kg. Mean therapy duration was 6.62±3.91 days. Mean therapy dose was 69647.69±95789.41 IU. Mean hospital stay was 11.71±5.84 days. Most common source of the micro-organism was blood. X–rays of 52.3% were found improved after 48 hours of treatment. Efficacy was among 90.3% patients. Conclusion: With 90.3% efficacy, polymyxin was well tolerated and better option for the management of MDR-GNB infections. Keywords: Efficacy, Intravenous Polymixin (Colistin), Multidrug Resistant Organisms, Sepsis.

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