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STUDY TO KNOW THE INCIDENCE AND SEVERITY OF LIVER DAMAGE IN PATIENTS OF TYPHOID FEVER ATTENDING TERTIARY CARE HOSPITAL

Dr Shanza Zafar, Dr Nafeesa, Dr Hifsa Akram

Objective: Liver involvement in typhoid fever is common. This study was conducted to determine the incidence and severity of liver damage in patients presenting with typhoid fever. Study Design: An Observational Study. Place and Duration: In the Gastroenterology department of Mayo Hospital Lahore for one year duration from November 2018 to October 2019. Methods: In this study patients only with positive blood culture for Salmonella Typhi were selected. Liver function tests and complete blood count were performed for all patients with liver function test disorder, viral hepatitis profile and ultrasound as an abdominal cyst. Results: A total of 52 patients met the inclusion criteria. Including hepatic manifestation in10% of cases, jaundice (13.4%), hepatomegaly (51.9%), high serum alanine aminotransferase levels (85%) more than 10 times the normal value, aspartate aminotransferase (75%), prothrombin time (53.8%). In 15.4% the PT was 3 seconds greater than the reference value, from alkaline phosphatase (44%) and from serum bilirubin (25%); Decreased serum albumin levels (38%). Other symptoms were splenomegaly (36.5%), anemia (55.7%), leukopenia (6%) and thrombocytopenia (44%). The mean hospital stay was 11.5 + 4.3 days. All patients were discharged healthy. Conclusion: In the presence of high-grade fever, tender hepatomegaly and jaundice, patients who have traveled from tropical countries or have recently had a high frequency of high thyroid fever should induce a suspected clinical diagnosis of enteric fever. In these cases, liver dysfunction is transient, despite its high incidence and severe nature, and responds favorably to appropriate antibiotic therapy. Key words: typhoid fever, liver dysfunction.

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