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TITLE:

ANALYSIS OF OXIDATIVE STRESS AS A MARKER OF CARDIOVASCULAR RISK IN CHILDREN ON REGULAR HEMODIALYSIS

AUTHORS:

Dr Wajid Ali, Dr Shawana Saeed, Dr Sajid Ejaz

ABSTRACT:

Abstract: Introduction: Chronic kidney disease (CKD) is a noteworthy general health issue around the world, and its fundamental outcomes incorporate loss of renal capacity prompting end-organize renal malady (ESRD), expanded danger of cardiovascular ailment (CVD), critical increment in horribleness and mortality, and a diminishing in health-related personal satisfaction. Aims and objectives: The basic aim of the study is to analyze the oxidative stress and total antioxidant capacity as a biomarker of cardiovascular risk in those children who are on regular hemodialysis. Methods: This cross sectional study was conducted at Children Hospital Lahore during February 2018 till September 2018. The data were collected from the age of less than 18 years children of both sexes. There were 50 children who was selected for this study. At the season of the examination, every one of the patients were on ordinary three HD sessions for every week; each time for 3– 4 h (all out 12 h week by week) for over 3 months with polysulfone dialyzing films, after creatinine freedom had fallen underneath 8– 12 or potentially pharmacological treatment and diet had demonstrated lacking to control clinical side effects. The mean dialysis term was 2.18±1.36. Results: The information were gathered from 50 dialysis patients. The mean age of this investigation is 15years. We gathered all the statistic information of patients. At before-dialysis session, span of malady emphatically associated with TPX, at the same time, adversely connected with TAC. At after-dialysis session, HIF-1α adversely corresponded with each of TPX and OSI; while, OSI decidedly associated with TPX. Conclusion: It is inferred that HD patients, the clinical and prognostic centrality of oxidative status related with cardiovascular hazard factors is altogether different from the all inclusive community.

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