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TITLE:

ARTERIAL STIFFNESS SUBSEQUENT CORONARY ARTERY BYPASS GRAFT, FACTOR OF PREDICTION FOR ACUTE KIDNEY INJURY

AUTHORS:

Dr Shawana Saeed, Dr Wajid Ali, Dr Hiba Raza

ABSTRACT:

Abstract: Outline: Acute kidney injury (CSA-AKI) after cardiac surgery, is considered to be serious postoperative complication that has a great impact on patient mortality. The instrument that has been used to forecast development of kidney disease through pulse wave velocity which holds imperative position in cardiovascular and chronic kidney disease. Our hypothesis considers that PWV (pulse wave velocity) can also predict the presence of acute injury of kidney (AKI) in patients, recently experienced coronary artery bypass graft (CABG), excluding valve repair. Method: The study was of an observational and exploratory nature where PWV was measured. The standard clinical parameters and biochemical controls were also used in the study. Results: We included 137 patients in our study of which 85 percent male subjects and the mean age being 66.3 years. The incidents of CSA and AKI were 29 percent. The increase in one unit of PWV could be the reason of 1.5 times more chances of AKI that is p = 0.006 (ratio 1.5 and interval surety: 1.13 to 2.10). Increase of one unit in glomerular filtration rate was found to decrease 85 percent in AKI development. It is also found that men who demonstrated reduction of 15 percent development of AKI as compared to females every year. Increase in age also lowers 87 percent chance of developing AKI. Conclusions: The study reveal that PWV independently predicts CSA and AKI events before the non-valve repair CABG and this technique is simple which can be used to assess risk of AKI-CSA after elective cardiac surgery.

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