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ANTIMICROBIAL SUSCEPTIBILITY PATTERNS AMONG ISOLATES OF HELICOBACTER PYLORI

Dr Atta-U-Rehman, Dr Abdul Sahban Shad, Dr Salma Aziz

Abstract: Objective: The aim of this research work is to assess the occurrence and antibiotic resistance among clinical isolates of H. pylori from Mayo Hospital Lahore. Methodology: We carried out the testing of anti-microbial susceptibility for one hundred and thirty-seven isolates of H. pylori gathered from three hundred and sixty-eight patients who were undergoing examination through endoscopy. We used four antibiotics amoxicillin, metronidazole, tetracycline & clarithromycin. Results: We observed a high rate of the resistance against the antibiotic of metronidazole as 48.20% followed by resistance against clarithromycin as 27.70%, amoxicillin as 14.60% & tetracycline as 9.50%. There were total 8.80% (n: 12) patients were as multidrug-resistant for the isolates of H. pylori as examined by this research work. We also noted the alarming sign for the development of the resistance to the antibiotics of amoxicillin, clarithromycin & tetracycline. Conclusion: This is very important requirement for the patients to know about the pattern of the resistance prevailing in their area during the selection of the antibiotics against the infections of H. pylori. Key Words: H. Pylori, Antibiotics, Clarithromycin, Antibiotics, Susceptibility, Metronidazole, Resistance, Amoxicillin, Endoscopy.

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