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STUDY TO KNOW THE CORRELATION OF GLYCEMIC CONTROL AND CHRONICITY OF DISEASE WITH MAGNITUDE AND FREQUENCY OF DISTAL PERIPHERAL NEUROPATHY IN PATIENTS NEWLY DIAGNOSED WITH TYPE II DIABETES MELLITUS

Dr Areeba Khan, Dr Muhammad Fawad Khan, Dr Muhammad Rehan

Abstract: Objective: To determine the frequency and severity of peripheral neuropathy in patients with type 2 diabetes mellitus. Study Design: An Experimental Study. Place and Duration: In the Physiology Department of Services Institute of Medical Sciences in collaboration with Medicine Unit II of Services Hospital Lahore for Six months duration from September 2018 to February 2019. Methods: Forty-two subjects with type 2 diabetes at the beginning were randomly selected into the experimental group. Twenty-five patients with age and sex matched were included as controls. Electromyography showed nerve conduction velocities of 2 sensory nerves and 2 motor nerves of upper and lower extremities. Glycemic control was assessed by the presence of fasting plasma glucose and glycosine Hb with the help of a kit. Conclusion: Peripheral neuropathy was 33.33% higher in diabetic men and 16.6% higher in women. Fasting plasma glucose levels showed a significant inverse correlation with sensory conduction of speeds (r = -0.365), sural (r = -0.366) and motor conduction speeds (r = -0.365) (P <0.05). 0.366) and motor conduction velocities (r = - 0.540). We found a significant inverse correlation (P <0.05) between glycated Hb and sensory and motor nerve conduction velocities. Conclusion: Nerve conduction rates should be performed regularly. In addition, glycosylated Hb levels should be monitored and controlled regularly so that peripheral neuropathy and disability in these patients can be prevented by appropriate and timely diagnosis and treatment. Key words: Distal peripheral neuropathy, diabetes, glycemic control.

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