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GALLSTONES AND CHOLECYSTECTOMY IN RELATION TO RISK OF LIVER CANCER: A META- ANALYSIS STUDY

Dr Hafiza Arooj Fatima,Dr Faiqa Azhar,Dr Farah Malik

Abstract: Background: The association between gallstones or cholecystectomy and the incidence risk of liver cancer is controversial. This is a meta-analysis of observational studies on the role of gallstones or cholecystectomy in primary liver cancer. Method: Relevant studies were identified after the literature search via electronic databases until 2018. Results: A random effects model was used to generate pooled multivariable adjusted odds ratios (ORs) and 95% confidence intervals (CIs). Heterogeneity among studies was evaluated using Cochran’s Q and I 2 statistics. A total of 14 studies (four case–control, 10 cohort) were included in this study. Our study showed the pooled OR was 2.66 (95% CI: 2.05–3.28) for gallstones with liver cancer risk and OR was 1.47 (95% CI: 1.24–1.71) for cholecystectomy. Though there was obvious heterogeneity among these studies, the risk of incidence was consistent in the subgroup analyses and sensitivity analysis. Conclusion: This meta-analysis showed that gallstones and cholecystectomy was associated with risk of liver cancer. The findings should be confirmed by future studies with validated questionnaires, well designed studies and strict control of confounders. Key Words: cholecystectomy, gallstone, liver cancer, meta-analysis.

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