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A RESEARCH STUDY TO INVESTIGATE THE ROLE OF OVARIAN FUNCTION AND ANDROGENS IN THE REPRODUCTIVE FUNCTION OF FEMALES

Dr. Umair Ashfaq, Dr. Amjad Ali Raza, Dr. Sarwat Saif

Abstract: Last decade investigations report that a direct and important role of androgens is crucial for the regulation of the reproductive system among females. Androgen receptor mediates the action of androgens which has been confirmed through mouse models. These AR-mediated androgens are important for the regulation of female fertility, ovulation, development and follicle health. This research proves the beneficial effects of the androgens through clinical data among poor respondents’ females which has improved the global concept of in vitro fertilization (IVF). An excessive androgen which acts as AR also plays an important role in PCOS origins (Polycystic Ovary Syndrome). The target sites identification for AR actions and related molecular mechanisms are also involved in the PCOS development which is mandatory to achieve the required level for the new future developments, PCOS treatments and mechanisms-based disease management. Our research summarizes related scientific discoveries which will increase the awareness about the importance of androgens among the reproductive function of the females. More effective future strategies may also be developed for the role of androgens in the physiology of the females with improved IVF outcomes with improved symptoms among PCOS patients. Keywords: Androgens, Reproductive, Receptors, Cell, Fertility, Follicle, Ovulation, Polycystic and Ovary.

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