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ANALYSIS OF VITAMIN D-BINDING PROTEIN AS A NEW BIOMARKER IN ANALYSIS OF NEPHROPATHY IN DIABETIC PATIENTS

Dr Tauqeer Ahmed, Dr Abdullah Arif, Dr Orooj Asif

Abstract: Introduction: Diabetes mellitus (DM) belongs to a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. The chronic hyperglycemia of diabetes is associated with long-term damage, dysfunction, and failure of different organs, especially the eyes, kidneys, nerves, heart, and blood vessels. Objectives: The main objective of our study is to find the role of vitamin-D as a biomarker in investigation of nephropathy in diabetic patients. Methodology of the study: The study was conducted at District Head Quarter Teaching hospital, Gujranwala during May 2018 till December 2018. For the purpose of study 100 patients were selected for further analysis. Those who selected for study were further goes for the analysis of Urine, creatine, Albumin and other series of test. Results: Lipid profile of the normal group and diabetic group shows the microalbuminuria and macroalbuminuria of diabetic group. The data presented in the table shows the total protein, serum albumin, serum urea, creatinine, GFR and some inflammatory marker which is vitamin-D. It shows the elevated levels of vitamin-D in diabetic patients. Conclusion: It is concluded that vitamin-D binding protein plays an important role and act as serum biomarker for the identification of diabetic nephropathy.

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