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TITLE:

DRUG-EXCIPIENT COMPATABILITY STUDYON TORSEMIDE USING CURRENT TRENDS AND TECHNIQUES

AUTHORS:

*P. Abhinandana and Ramarao Nadendla

ABSTRACT:

Abstract: A study of drug and excipient compatibility plays a major role in a pre-formulation study which is further useful in the development of dosage forms. The interaction between drug and excipient will affect the chemical nature and bioavailability of the drug which may test the safety and efficacy of the drug. Present research work was done to study the compatibility between Torsemideand different pharmaceutical excipients like cross-povidone (CP) , magnesium stearate (MS) , microcrystalline cellulose (MCC) and Anhydrous lactose (AL) by different analytical techniques like FTIR(Fourier transform infrared spectroscopy), UV-Visible spectroscopy, DSC (Differential scanning calorimetry) and RP-HPLC (Reverse Phase High performance liquid chromatography).The spectral datashows that excipients used in this study areineffective with Torsemide. Key words:Torsemide, excipients,FTIR, UV , DSC and RP-HPLC.

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