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TO DETERMINE THE EFFECTS OF CLOPIDOGREL IN PLATELET AGGREGATION INHIBITION

Dr Saima Riasat, Dr Rabia Shaheen, Dr Shamroz Aslam.

Abstract: Objective: To evaluate the in vivo Clopidogrel 75 mg (Lowplat) therapeutic effects. Study Design: A multicentre and an open study. Place and Duration: In the Medicine Units of Jinnah and Services Hospital Lahore in collaboration with Cardiology department for one-year duration from May-2018 to May-2019. Methodology: This study is multicentre and an open study to conclude the inhibition of aggregation of platelet of analytic drug in adult patients who were taking antiplatelet therapy, ie peripheral vascular disease (PVD), cerebrovascular accident (CVA) and coronary artery disease (CAD). Results: 66% inhibition of Mean platelet aggregation is done by Lowplat (P <0.001) with ± 10% standard deviation, which was significant statistically. Conclusion: This analysis demonstrates that (LP) Lowplat is operative in significantly decreasing platelet aggregation in subjects requiring antiplatelet treatment. The price advantage of locally produced drugs can be given to patients. Key Words: Antiplatelet therapy, Clopidogrel, platelet aggregation inhibition.

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