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PREVALANCE OF LIPID PROFILE AND LIPID PEROXIDATION STATUS IN SCHIZOPHRENIC PATIENTS RECEIVING ANTI-PSYCHOTIC DRUGS: A COMPARATIVE STUDY FROM LAHORE-PAKISTAN

Iram Shahzadi, Hafiz Muhammad Arsalan, Saira Naseem, Zeemal Seemab Amin, Farooq Saleem, Maria Altaf, Sania Iftikhar, Ayesha Mehmood, Iqra Maqsood, Nazia Gulshan

Abstract: Background: Dopaminergic movement in the prefrontal cortex are related with the shortfall side effects and psychological impedance of schizophrenia and that expanded action in the sub cortex is related with the insane manifestations of schizophrenia. A partial employment of glutamatergic transmission in oxytocin mediated choking of dopaminergic psycho stimulant induced practices has in like manner been proposed. Objective: To determine the Lipid Peroxidation status in schizophrenic patients receiving anti-psychotic drugs. Methodology: Comparative Study. Fourty patients of Schizophrenia and Fourty age and sex-matched healthy individuals were eligible for inclusion in the study at Mental Hospital Lahore. 5.0 ml blood sample was taken from each individual and subjected to centrifuge at 3500-4500 rpm for 10-15 minutes for the separation of serum. Oxidative stress biomarkers (NO, MDA, AOPP and AGE’s) and serum electrolyte profile, Serum LFT’s, Serum RFT’s and serum Lipid Profile were estimated. Results: NO level in schizophrenic patients is (0.17 ± 0.10), while NO level in sound people (12.3±2.05) Data also shows that NO is significant statistically (P = 0.000<0.05). MDA level in schizophrenic patients is (0.23±0.08), while MDA level in healthy individuals (1.27±0.28). Information additionally demonstrates that MDA is critical factually (P = 0.000<0.05). Na+ level in schizophrenic patient’s is (78.93±59.46), while Na+ level in healthy persons (141.5±2.05). Data other than presentations that Na+ is key truly (P = 0.000<0.05). Conclusion: Present study concluded that serum total protein, sodium (Na+), NO, AGE,s and AOPP level declined remarkably which is the cause for the progression of disease. Key Words: NO, MDA, AGE’s, AOPP, Lipid Peroxidation.

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