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SYNTHESIS AND SCREENING OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY OF NOVEL BENZTRIAZOLE DERIVATIVES

Padmaja Devi M. S*, Dr. Prasobh G.R., Dr. Sandhya S.M, Visal C S, Reena, Athira

Abstract: Benzotriazole is a lead molecule for designing potential bioactive molecule. Benzotriazole and its derivatives exhibits anti inflammatory, analgesic, antimicrobial and anticonvulsant activities. 1,2,4 triazole is one of the most biologically active classes of compounds possessing wide spectrum of activities including anti-inflammatory, analgesic, CNS stimulants, sedatives, antianxiety, antimicrobial agents and antimycotic agents. In this study, we planned to synthesize various Schiff’s bases of 5 [1H,1,2,3 benzotriazol 1yl methyl] 4 [substituted amino]4H-1,2,4 triazole-3 – thiol. Finally characterization and pharmacological screening of synthesized derivatives were done for its antifungal activity. Keywords: Benzotriazole, antiinfammatoryl, Schiff’s bases.

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