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ANTIDIABETIC ACTIVITY OF ETHANOL EXTRACT OF SONI LEAVES (DILLENIA CELEBICA HOOGLAND.) ON BLOOD GLUCOSE LEVELS AND PANCREATIC HISTOLOGY OF MALE WISTAR RATS GLUCOSE-INDUCED

Henny Kasmawati*, Ruslin, Sunandar Ihsan, Hasnawati, Suryani, Brigita Anugrah Pertama, Sinar Ayu Farida

Abstract: Objective: Determine the potential, effectiveness and histology of pancreatic organs of wistar male rats with type II diabetes after glucose induction by giving ethanol extract of soni leaves (Dillenia celebica Hoogland.). Method: Experimental with pre-post test randomized control group design. One-Way Anova Statistics to see a decrease and percent decrease in blood glucose levels. The histology of the pancreatic organs is based the number of endocrine cells the islet of Langerhans using a microscope. Diabetes mellitus modeling by oral glucose-induced dose 20g/kgbw. The rats were divided into 6 groups, namely Normal Control, Negative Control, Positive Control and Group given ethanol extract of Soni leaves at a dose 29,78 mg/kgbw, 59,57 mg/kgbw, 120,74 mg/kgbw, respectively. Results: Ethanol extract of soni leaves has the potential as antidiabetic which was significantly different (p˂0.05) to the negative control group and at a dose 120.74 mg/kgbw has the same effectiveness as glibenclamide (p<0,05) in reducing blood glucose levels. And the histology of the pancreatic organs compared to the positive control group on a dose 120,74 mg/kgbw has the same ability to regenerate endocrine cells as indicated by improvements the Langerhans islet based the number of regenerated endocrine cells with the number of cells 415 and 410 cells. Conclusion: Ethanol extract of soni leaves has the potential and effectiveness in reducing blood glucose levels and has the effectiveness of regenerating pancreatic β cells on langerhans. Keywords : Dillenia celebica Hoogland, Glucoce, Antidiabetic, Pancreatic Histology.

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