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ROLE OF BRANCHED CHAIN AMINO ACID IN THE ACHIEVEMENT OF HEPATIC ENCEPHALOPATHY EARLY REVERSAL AMONG ADVANCED LIVER DISEASE PATIENTS

Dr. Saba Asghar, Dr Muhammad Hassan Shahbaz, Dr Muhammad Fahad Faiz

Abstract: Objectives: The objective of this research was to compare the occurrence of hepatic encephalopathy early reversal among without BCAA (Branched Chain Amino Acid) liver disease patients. Methodology: This research was carried out at Mayo Hospital, Lahore from August 2017 to July 2018. The research sample included 100 patients who were further divided into groups of fifty each as Group I & II having Grade III or IV Hepatic encephalopathy and Splenomegaly and coarse liver as observed through USG. The patients were selected from both male and female gender having age from 30 to 60 years. Demographic information included address, name, and age which was kept confidential. Data entry and analysis was carried out through SPSS software with documentation of change of hepatic encephalopathy grades. Results: The predominant age group was from 41 to 50 years having a respective representation of 22 patients in Group – I (44%) and 26 patients in Group – II (52%). Mean and SD values for Group I & II were respectively (43.98 ± 3.76) and (44.32 ± 3.02). Group – I had 33 males (66%) and 17 females (34%); whereas, Group – II had 29 males (58%) and 21 females (42%). Hepatic encephalopathy early reversal among advanced liver disease patients with BCAA in Group – I was reported in 32 patients (64%) and in Group – II in 13 patients (26%); whereas, without BCAA in Group – I was in 18 patients (36%) and Group – II in 37 patients (74%) (P-Value = 0.00). Conclusion: The hepatic encephalopathy early reversal occurrence among advanced liver disease patients with BCAA and without BCAA shows that BCAA treated patients achieved hepatic encephalopathy early reversal. Keywords: Early Reversal, Advance Liver Disease, BCAA (Branched Chain Amino Acid), Hepatic Encephalopathy, Grade and Infection.

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