ResearcherID - CLICK HERE Scientific Journal Impact Factor (SJIF-2020) - CLICK HERE

BONE MINERAL DISEASE IN PATIENTS WITH CHRONIC KIDNEYDISEASE

Dr. Pooran Mal, Abdul Ghani Rahimoon, Dr. Muhammad Nadeem Ahsan, Dr. Hamid Nawaz Ali Memon, Dr. Imran Karim and *Dr. Samar Raza

Objective: To explore the bone mineral disease in patients with chronic kidney disease. Patients And Methods:A total of fifty patients of chronic kidney disease were explored and included in the study. The cross-sectional survey includes newly patients diagnosed as CKD by the abbreviated modificationof diet in renal disease formula, biochemical and ultrasonographic / histological evidence of CKD while the exclusion criteria were those who had preexisting parathyroid abnormalities already on non-steroidal anti inflammatory drug, antiepileptics, known hepatic diseases, rickets, osteomalacia and renal transplant patient. After informed consent with aseptic precautions, about 8 ml of venous blood was obtained to analyze for serum vitamin D, intact PTH and plain radiograph for bone lesions and BMD was measured by dual-energy X-ray absorptiometry to estimate the T-score whereas the frequency / percentages (%) and means ±SD computed for study variables. Results:During six month study period total fifty patients with chronic kidney disease were explored and study. the mean ± sd for age (yrs) of population was 51.88±7.51. Regarding gender male 32 (64%) and female 18 (36%), hypocalcemia 36 (72%), vitamin d deficiency 35 (70%), hypomagnesemia 26 (52%), hyperphosphatemia 29 (58%) and z-scores on dxa ≤2 (56%) and parathyroid hormone was raised in 32 (64%), normal 08 (16%) and low in 10 (20%) individuals. Conclusion:Vitamin D lack and high pervasiveness of unsettling influences of other mineral digestion including hyperparathyroidism and abnormal BMD is noted in initial phases of CKD. KeyWords: Bone mineral disease and chronic kidney disease

FULL TEXT