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PREFORMULATION STUDY ON ENHANCING THE SOLUBILITY OF LORNOXICAM WITH HYDROPHILIC CARRIERS

Lubna Nousheen* and S. Rajasekaran

Preformulation testing is the first step in the rational development of dosage forms of a drug substance. For low aqueous solubility drugs, the challenge of making solid dispersions is in choosing the amount of carrier that would increase the aqueous solubility while keeping the overall oral dosage size small. The main objective of the present research work was to do a preformulation study of Lornoxicam (LOR), A nonsteroidal anti-inflammatory drug (NSAID). In this research, the Lornoxicam was analysed for solubility, pH effect, melting point, moisture content, powder flow properties, and compatibility with different carriers. The solubility of Lornoxicam was estimated in distilled water and pH 6.8 phosphate buffer medium; Lornoxicam showed higher solubility in pH 6.8 phosphate buffer than distilled water. The selection of polymers for the preparation of solid dispersions; hydrophilic carriers such as Poloxamer 188, Poloxamer 407, PEG 4000, PEG 6000, and PVP K-30 at different concentrations on the equilibration solubility of Lornoxicam in pH 6.8 phosphate buffer medium at room temperature was carried and found that the solubility of lornoxicam simultaneously increased with increasing carrier concentrations. The FTIR spectroscopic studies showed the stability of LOR. The DSC and XRD studies indicated that the Lornoxicam was in crystalline. Keywords: Lornoxicam, Solubility, Preformulation Study, Hydrophilic Carriers.

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