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STUDY TO KNOW THE CLINICO-HEMATOLOGICAL FEATURES OF ACUTE MYELOID LEUKEMIA AND ITS FREQUENCY

Dr Pir Zada,Dr Ahmad Shair, Dr Ghulam Subhani

Abstract: Objective: To evaluate the frequency and clinical hematological features of AML. Study design: 3-year prospective cross-sectional observation study. Place and Duration: In the Medicine Unit II of Services Hospital Lahore in Collaboration with haematology department for three years duration from March 2016 to March 2019. Methodology: The AML newly diagnosed in all age groups and in both sexes were selected. Exclusion criteria, already diagnosed patients, were on radiotherapy or chemotherapy of AML. A detailed history including the presentation age of the disease and general and physical examination was obtained. History of exposure to drugs, chemicals and work history was recorded. Laboratory analysis included complete blood count and bone marrow examination. Results: The incidence of ALL in 82 patients with acute leukemia was 47 (57.3%) and AML was 35 (42.7%). Of the 35 patients with AML, 21 (60%) were male and 7 (40%) were female. Of these 35 patients, 24 (68.6%) were adults (> 15 years) and 11 (31.4%) were children (<15 years). Regarding subtypes of AML, M3 was more common than all of them and the frequency was estimated to be 13 (37%), M2 (10 (29%)), M1 (20%), M4 (3), respectively. (8%). and M6 was 2 (6%). The most usual complaints were bleeding, fever and pallor. The constitutional findings were splenomegaly, hepatomegaly, lymphadenopathy, hypertrophy of the gums, petechiae and contusions. Soft tissue infiltration by leukemic cells was common in AML-M3 and M1. Conclusion: Acute myeloid leukemia is more common in adults with superiority in men. Clinical manifestations vary in different subtypes. Key words: Leukemia, AML, frequency, Subtypes of AML, clinical features.

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