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TITLE:

STABILITY INDICATING METHOD DEVELOPMENT AND VALIDATION AND SIMULTANIOUS ESTIMATION OF DAPAGLIFLOZIN AND SAXAGLIPTIN IN PHARMACEUTICAL DOSAGE FORM

AUTHORS:

Santhosh Illendula*, Mallepally Sandeep Kumar, Dr. K.N.V.Rao, Dr. Rajeswar Dutt

ABSTRACT:

Abstract: A straightforward, precise, exact technique was developed for the evaluation of the Dapagliflozin&Saxagliptinin tablet dosage form. Chromatogram was run through Altima 150 x 4.6 mm, 5m. Mobile phasecarryingBuffer0.1%OPA:ACN in use in the %50:50was injecting into column at a flow rate of 1ml/min and 220nm. Runtime of Dapagliflozin&Saxagliptin was initiate to 2.691min and 2.143min. %RSD of the drugs were and get to be 0.8and 0.5 in the same way. %Recovery was get as 100.42% and 100.15%. LOD, LOQ values get from regression sum of Dapagliflozin&Saxagliptin were 0.52, 1.57 and 0.48, 1.44 likewise. Regression sum of Dapagliflozin is y = 11821x + 1957, and y =7209x + 2179 of Sitagliptin. The drugs were observed to be stable and less apt to degradation when they are subjected to a variety of stress conditions. Key Words: Dapagliflozin, Sitagliptin, RP-HPLC.

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