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A COMPARISON OF SENSITIVITY AND SPECIFICITY OF TRANSIENT ELASTOGRAPHY I.E. FIBRO SCAN WITH SERUM AMINOTRANSFERASE LEVELS I.E. ALT & AST IN CHRONIC HCV INFECTED PATIENTS, A RETRO PROSPECTIVE CROSS-SECTIONAL STUDY AT LAHORE GENERAL HOSPITAL, LAHORE, PAKISTAN

Syed Muhammad Aqib, Bukhtawar Munir, Sifwa Safdar, Azhar Hussain, Dr. Junaid Mushtaq

Abstract: Objective: To assess the validity of Serum Aminotransferase Levels i.e. ALT & AST as fibrosis biomarker, we compared their serum levels with fibro scan for the fibrosis staging and predicting its progression in Pakistani population. Methods: The retroprospective cross sectional study was conducted in medicine unit 1&2 and hepatitis clinic of Lahore General Hospital, Lahore starting from February 15, 2018 to January 11, 2019. We studied 1181 HCV infected patients which were got CBC, LFTs, ELISA, PCR and fibro scan done to perfectly diagnose ongoing hepatitis C infection . In order to differentiate HCV fibrosis progression, we compared the effectiveness of readily available serum aminotransferase Levels i.e. ALT & AST with fibro scan. Results: An AST had sensitivity of 82.6 and specificity of 79.0 for F4 stage. with AUC=0.883. An ALT for F4 stage, the sensitivity was 57.3, specificity 50.0 with AUC=0.771. Conclusion: An AST and ALT can predict advance stage of fibrosis and cirrhosis in patients with chronic hepatitis C infection. In these patients, a liver biopsy and fibro scan may not be necessary. Keywords: Hepatitis C, Blood Platelets, Fibro scan score.

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