Dr Zaineb Haider, Dr. Muhammad Aleem Haider, Dr Mariam Saeed
Introduction: The role of maternal exposure to environmental contaminants on the developing fetal immune system is not clear. It has been suggested that fetal exposure to some environmental contaminants can promote life-long changes to the developing immune system that would have an effect on immune system responses resulting in an increased risk of an allergic phenotype in childhood and beyond. Aim of the study: The basic aim of the study is to find the risk factors and blood biomarkers of allergy during pregnancy in females. Methodology of the study: This cross-sectional study was conducted at Central Park Medical College, during March 2019 to October 2019. For this purpose, we select the 100 pregnant women which was at different stages of pregnancy. Then we collect the blood samples of each women for further biochemical analysis and antioxidants analysis. We designed a study to associate maternal BMI and GWG with pregnancy outcomes in local women of Pakistan with biomarkers of allergy and antioxidants and examine whether these are predictive of adverse perinatal outcomes in Pakistani population. Result: Serum allergy biomarkers shows that in pregnancy women become more sensitive to allergy as compared to normal condition. The levels of inflammatory biomarkers in blood is at increased level as compared to normal women. The levels of IL-6 and IL-8 was significantly higher in pregnant women. Conclusion: It is concluded that positive, statistically significant association between maternal allergy biomarkers exposure and elevated cord blood concentrations of the epithelial cell derived cytokines TSLP and IL-6 and 8.