::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

RHINOVIRUS CONTAMINATION CAUSES CORRUPTION OF ANTIMICROBIAL PEPTIDES AND FACULTATIVE BACTERIAL CONTAMINATION IN CONSTANT OBSTRUCTIVE PULMONARY DISEASE

AUTHORS:

Dr Rubab Kiran Butt, Dr.Usman Akhtar, Dr Aqsa Zulfiqar

ABSTRACT:

Intro: Exacerbations of Chronic Obstructive Pulmonary Disease are related through viruses (mostly rhinoviruses) and bacteria, but authors don't recognize if rhinovirus contagions precipitate secondary bacterial infections. Objectives: To study the associations among rhinovirus infection also bacterial contagion and role of antimicrobial peptides in COPD exacerbations. Methods: Our current research was conducted at Sir Ganga Ram Hospital, Lahore from April 2018 to March 2019. We infected reasonable COPD subjects and smokers and non-smokers by normal lung role through the rhinovirus. Persuaded sputum remained collected before and after rhinovirus contamination. And viral and bacterial loads restrained through quantitative polymerase chain reaction also culture. Secretory leucopyrites of antimicrobial peptides, elfin, pentraxin, LL-37, a-defensins andb-defensin-2, and neutrophil elastase protease remained restrained in sputum supernatants. Measurements and Main Results: After rhinovirus infection, secondary supernatants bacterial contagion remained perceived in 63% of COPD patients, 12.52 of smokers and 12% of non-smokers (P, 0.002). Sputum viral load reached its maximum from day 5 to day 10 and bacterial load from day 15. Sputum Neutrophil elastase remained raised significantly, and SLPI and elfin were increased. Reduced after rhinovirus contagion exclusively in COPD cases through secondary bacterial infections, also SLPI and elafin levels correlate inversely to the bacterial load. Conclusions: Rhinovirus infections are frequently followed through bacterial illnesses in COPD and antimicrobial cleavage SLPI and elf peptides through neutrophil elastase triggered by infection might encourage those bacterial helper illnesses. It may be useful to focus on treatments for neutrophil elastase or on improving intrinsic resistance. New therapies to avoid the bacterial ancillary diseases in infections that cause COPD to intensify. Keywords: Rhinovirus contamination, antimicrobial peptides, pulmonary disease