::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

FREQUENCY OF IN-HOSPITAL MORTALITY IN PATIENTS WITH HIGH NEUTROPHIL/LYMPHOCYTE RATIO AS MARKER OF DISEASE ACTIVITY IN ANKYLOSING SPONDYLITIS

AUTHORS:

Dr Saqiba Khan, Dr Abdul Ghaffar Khan, Dr Muhammad Usama Hassan

ABSTRACT:

Introduction: Ankylosing spondylitis (AS) is a systemic chronic inflammatory condition involving mainly sacroiliac joint and spine. Objectives: The purpose of this study is to find the frequency of in-hospital mortality in patients with high neutrophil/lymphocyte ratio as marker of disease activity in ankylosing spondylitis. Material and methods: This cross-sectional study was conducted in SIMS, Lahore during March 2019 to January 2020. All patient who have ankylosing spondylitis will be assessed and those who fulfill the inclusion criteria will be included in study group. All patients will be assessed using BASDAI and BASFI for disease activity. Results: The patient group consisted of 35 patients (26 men (74.3%) and 9 women (25.7%)), and the control group consisted of 38 healthy volunteers (26 men (68.4%) and 12 women (31.6%)). Mean age of the patients and healthy controls was 38.9±11.9 and 37.3±6.9, respectively. A total of 27 patients had HLA-B27 analysis; 15 (68.2%) of them were found to be positive. Four (12.9%) patients had a history of uveitis. Thirteen (46.4%) patients had enthesitis, and 14 (43.8%) patients had peripheral arthritis. Conclusion: It is concluded that neutrophil lymphocyte ratio can be a valuable and reliable tool of disease activity in mortality of in-hospital patients who have started anti-tumor necrosis factor (TNF) drugs for AS.